Uses of Zuviston tablet (Dydrogesterone)

Zuviston 

Uses :
Zuviston 10's tablet is used to regulate the uterus lining in postmenopausal women receiving estrogens who have not removed their uterus through surgery. It also helps treat amenorrhea (cessation or irregular menses cycle for more than three months).

Therapeutic indication 

Progesterone deficiencies 

• Treatment of dysmenorrhoea.
• Treatment of endometriosis. 
• Treatment of secondary amenorrhoea.
• Treatment of irregular cycles.
• Treatment of dysfunctional uterine bleeding. 
• Treatment of pre-menstrual syndrome.
• Treatment of threatened abortion.
• Treatment of habitual abortion.
• Treatment of infertility due to luteal insufficiency.
• Luteal Support as a part of Assisted Reproductive Technology (ART) treatment.

Hormone replacement therapy

To counteract the effects of unopposed oestrogen on the endometrium in hormone replacement therapy for women with disorders due to natural or surgical induced menopause with an intact uterus.

Posology and method of administration

Dosages, treatment schedule and duration of treatment may be adapted to the severity of the dysfunction and the clinical response.

Dysmenorrhoea : 10 or 20 mg Dydrogesterone per day from day 5 to day 25 of the Menstrual cycle.

Endometriosis : 10 to 30 mg Dydrogesterone per day from day 5 to day 25 of the cycle or continuously.

Dysfunctional uterine bleeding : When treatment is started to arrest a bleeding episode, 20 or 30 mg Dydrogesterone per day is to be given for up to 10 days.

For continuously treatment, 10 or 20 mg Dydrogesterone per day should be given during the second half of the menstrual cycle. The starting day and the number of treatment days will depend on the individual cycle length.

Withdrawal bleeding occurs if the endometrium has been adequately printed with either endogenous or exogenous estrogen.

Secondary amenorrhoea : 10 or 20 mg Dydrogesterone per day, to be given daily for 14 days during the second half of the day theoretical menstrual cycle to produce an optimum secretory transformation of an endometrium that has been adequately primed with either endogenous or exogenous estrogen.

Pre-menstrual syndrome : 10 mg Dydrogesterone twice daily starting with the second half of the menstrual cycle until the first day of the next cycle. The starting day and the number of treatment days will depend on the individual cycle length.

Irregular cycles : 10 or 20 mg Dydrogesterone per day starting with the second half of the menstrual cycle until the first day of the next cycle. The starting day and the number of treatment days will depend on the individual cycle length.

Contraindications :

1. Hypersensitivity to the active substance or to any to the excipient.
2. Known or suspected progestogen dependent neoplasms (e.g. meningioma).
3. Undiagnosed vaginal bleeding.
4. If used to prevent endometrial hyperplasia (in women using estrogens) : Contraindications for uses of oestrogens in combination with progestagens, such as Dydrogesterone.

Composition of medicines :

• Dydrogesterone ............ 10 mg

Dydrogesterone :
Dydrogesterone tablet is a hormonal therapy used to treat progesterone deficiency states. It can relieve menstrual pain and can treat symptoms of endometriosis and premenstrual syndrome. It can also be used to treat infertility problems and irregular periods in women.