Mela White
Composition : Hydroquinone USP ............................................. 2%w/wTretinoin USP ..................................................... 0.025%w/wMometasone Furoate IP ...................................... 0.10%w/w
PHARMACOLOGY
Hydroquinone is classified therapeutically as a depigmenting agent. Tretinoine is all trans retinoic acid formed from the oxidation of the aldehyde group of retinene to a carboxyl group. Tretinoin is classified as a keratolytic agent. Mometasone furoate is a synthetic corticosteroid with anti-inflammatory activity.
The combination agents in MELA WHITE act by inhibiting one or more steps in the tyrosine-tyrosinase pathway of melanin synthesis. It also effects the formation of melanization and degradation of melanosomes and even-tually causes necrosis of the whole melanocytes. The hyperpigmentation areas fade rapidly than surrounding normal skin; 80% of patients with melasma may note some improvement within 8 week period.
INDICATIONS :
MELA WHITE cream is indicated for the gradual bleaching of hyperpigmented skin conditions such as cholasma, malasma, freckles, senile lentigines and other unwanted areas of melanin hyperpigmentation.
CONTRAINDICATIONS :
Prior history or allergic reaction of Hydroquinone, Tretinoin and Mometasone.
The safety of Metamet during pregnancy and children (12 years and under) has not been established. Caution to be exercised when MELA WHITE is administered to nursing woman.
PRECAUTIONS :
Strictly for external use only.
Important to avoid contact with eyes, mouth and mucous membrane. Exposure to sunlight or UV light will cause repigmentation of bleached area.
ADVERSE REACTIONS :
The adverse reactions reported are dryness, fissuring of paranasal and infraorbital areas, erythema and stinging. Occasional hypersensitivity (Localized contact Dermatitis) may develop.
If hypersensitivity occurs, discontinue the medications and consult Physician immediately.
DIRECTION FOR USE :
MELA WHITE should be applied preferably once daily in the evening.
Duration of application would be decided by the physician depending upon the response.
STORAGE :
Store in a dry well-ventilated place at a temperature not exceeding 30'C.
Protect from light. Do not freeze. Keep cap close after use.
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